Radiotherapy
Also known as: radiation therapy · radiation · RT
Treatment modality that appears across the library’s GBM studies: in vivo Perturb-seq in mouse models showed radiotherapy rewires transcriptional responses to genetic perturbations; BRD2 bromodomain ablation increased radiation sensitivity in xenografts; TumorTwin demonstrates radiotherapy-response modelling in high-grade glioma. VC0070 VC0095 VC0134
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| Radiotherapy | associated with | Mesenchymal-like state | low | VC0069 supports Recurrent GBM shows a mesenchymal shift after therapy, but whether therapy induces or selects MES-like cells is unresolved. |
| TumorTwin | associated with | Radiotherapy | high | VC0134 supports Demonstration of radiotherapy-response modelling in high-grade glioma; no prospective clinical validation. |
| BRD2 | associated with | Radiotherapy | medium | VC0095 supports Genetic ablation of BRD2 bromodomains increased radiation sensitivity in xenografts. |
Appears in research topics
- Mesenchymal-like (MES-like) glioblastoma cell state (Cell states)
- Perturbation data for glioblastoma: radiotherapy, drugs and CRISPR (Perturbations)
- Therapy-induced plasticity in glioblastoma (Transitions)
Appears in library items (3)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0134 TumorTwin: a Python framework for patient-specific digital twins in oncology — Kapteyn et al., BMC Med Inform Decis Mak, 2026
- VC0095 BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma. — Vadla R et al., Neuro-oncology, 2025
- VC0070 In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma. — Liu SJ et al., Genome biology, 2024
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.