{"id":"radiotherapy","type":"method","name_en":"Radiotherapy","name_zh":"放射治疗","aliases":["radiation therapy","radiation","RT"],"description":{"en":"Treatment modality that appears across the library’s GBM studies: in vivo Perturb-seq in mouse models showed radiotherapy rewires transcriptional responses to genetic perturbations; BRD2 bromodomain ablation increased radiation sensitivity in xenografts; TumorTwin demonstrates radiotherapy-response modelling in high-grade glioma.","zh":"文献库 GBM 研究中常见的治疗方式：小鼠体内 Perturb-seq 显示放疗重塑对基因扰动的转录反应；BRD2 溴结构域敲除在异种移植中提高放射敏感性；TumorTwin 演示了高级别胶质瘤放疗反应建模。"},"externalIds":{},"graphNames":["radiotherapy"],"mentions":{"items":["VC0070","VC0134"],"topics":["cell-state-mes-like","perturbation-gbm-therapy","transition-therapy-induced-plasticity"]},"evidenceRefs":["VC0070","VC0095","VC0134"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/radiotherapy/","page_url_zh":"https://gliostate.com/zh/entities/radiotherapy/","api_url":"https://gliostate.com/api/entities/radiotherapy.json","external_links":[],"source_file":"https://gliostate.com/data/entities/radiotherapy.json","evidence_items":[{"id":"VC0070","title":"In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.","year":"2024","page_url":"https://gliostate.com/library/VC0070/","api_url":"https://gliostate.com/api/items/VC0070.json"},{"id":"VC0095","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","year":"2025","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"},{"id":"VC0134","title":"TumorTwin: a Python framework for patient-specific digital twins in oncology","year":"2026","page_url":"https://gliostate.com/library/VC0134/","api_url":"https://gliostate.com/api/items/VC0134.json"}],"mentioned_in_items":[{"id":"VC0070","title":"In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.","year":"2024","page_url":"https://gliostate.com/library/VC0070/","api_url":"https://gliostate.com/api/items/VC0070.json"},{"id":"VC0134","title":"TumorTwin: a Python framework for patient-specific digital twins in oncology","year":"2026","page_url":"https://gliostate.com/library/VC0134/","api_url":"https://gliostate.com/api/items/VC0134.json"}],"mentioned_in_topics":[{"id":"cell-state-mes-like","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"id":"perturbation-gbm-therapy","title_en":"Perturbation data for glioblastoma: radiotherapy, drugs and CRISPR","title_zh":"胶质母细胞瘤扰动数据：放疗、药物与 CRISPR","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"},{"id":"transition-therapy-induced-plasticity","title_en":"Therapy-induced plasticity in glioblastoma","title_zh":"胶质母细胞瘤的治疗诱导可塑性","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}],"relations":[{"subject":"radiotherapy","subject_name_en":"Radiotherapy","subject_name_zh":"放射治疗","predicate":"associated_with","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0069","role":"supports","title":"A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.","page_url":"https://gliostate.com/library/VC0069/","api_url":"https://gliostate.com/api/items/VC0069.json"}],"note":{"en":"Recurrent GBM shows a mesenchymal shift after therapy, but whether therapy induces or selects MES-like cells is unresolved.","zh":"复发 GBM 在治疗后出现间充质转变，但治疗是诱导还是筛选 MES 样细胞尚未解决。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]},{"subject":"tumortwin","subject_name_en":"TumorTwin","subject_name_zh":"TumorTwin","predicate":"associated_with","object":"radiotherapy","object_name_en":"Radiotherapy","object_name_zh":"放射治疗","confidence":"high","evidence":[{"id":"VC0134","role":"supports","title":"TumorTwin: a Python framework for patient-specific digital twins in oncology","page_url":"https://gliostate.com/library/VC0134/","api_url":"https://gliostate.com/api/items/VC0134.json"}],"note":{"en":"Demonstration of radiotherapy-response modelling in high-grade glioma; no prospective clinical validation.","zh":"演示高级别胶质瘤放疗反应建模；无前瞻性临床验证。"},"sources":[{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]},{"subject":"brd2","subject_name_en":"BRD2 (bromodomain containing 2)","subject_name_zh":"BRD2（含溴结构域蛋白 2）","predicate":"associated_with","object":"radiotherapy","object_name_en":"Radiotherapy","object_name_zh":"放射治疗","confidence":"medium","evidence":[{"id":"VC0095","role":"supports","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"note":{"en":"Genetic ablation of BRD2 bromodomains increased radiation sensitivity in xenografts.","zh":"在异种移植中，基因敲除 BRD2 溴结构域提高了放射敏感性。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}]}],"related_entities":[{"id":"mes-like-state","type":"cell_state","name_en":"Mesenchymal-like (MES-like) state","name_zh":"间充质样（MES 样）状态","page_url":"https://gliostate.com/entities/mes-like-state/","page_url_zh":"https://gliostate.com/zh/entities/mes-like-state/","api_url":"https://gliostate.com/api/entities/mes-like-state.json","via":"relation"},{"id":"tumortwin","type":"model","name_en":"TumorTwin","name_zh":"TumorTwin","page_url":"https://gliostate.com/entities/tumortwin/","page_url_zh":"https://gliostate.com/zh/entities/tumortwin/","api_url":"https://gliostate.com/api/entities/tumortwin.json","via":"relation"},{"id":"brd2","type":"gene","name_en":"BRD2 (bromodomain containing 2)","name_zh":"BRD2（含溴结构域蛋白 2）","page_url":"https://gliostate.com/entities/brd2/","page_url_zh":"https://gliostate.com/zh/entities/brd2/","api_url":"https://gliostate.com/api/entities/brd2.json","via":"relation"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"perturb-seq","type":"method","name_en":"Perturb-seq","name_zh":"Perturb-seq（扰动单细胞测序）","page_url":"https://gliostate.com/entities/perturb-seq/","page_url_zh":"https://gliostate.com/zh/entities/perturb-seq/","api_url":"https://gliostate.com/api/entities/perturb-seq.json","via":"co-mention"},{"id":"ap-1","type":"pathway","name_en":"AP-1 transcription factor complex","name_zh":"AP-1 转录因子复合物","page_url":"https://gliostate.com/entities/ap-1/","page_url_zh":"https://gliostate.com/zh/entities/ap-1/","api_url":"https://gliostate.com/api/entities/ap-1.json","via":"co-mention"},{"id":"crispri","type":"method","name_en":"CRISPR interference (CRISPRi)","name_zh":"CRISPR 干扰（CRISPRi）","page_url":"https://gliostate.com/entities/crispri/","page_url_zh":"https://gliostate.com/zh/entities/crispri/","api_url":"https://gliostate.com/api/entities/crispri.json","via":"co-mention"},{"id":"delphai","type":"model","name_en":"DELPHAI","name_zh":"DELPHAI","page_url":"https://gliostate.com/entities/delphai/","page_url_zh":"https://gliostate.com/zh/entities/delphai/","api_url":"https://gliostate.com/api/entities/delphai.json","via":"co-mention"}]}