NF1 (neurofibromin 1)
Also known as: NF1 · neurofibromin 1
Gene whose alterations favour the MES-like state in the Neftel glioblastoma framework, where state frequencies are shaped by CDK4, EGFR and PDGFRA amplifications and NF1 mutations. VC0059
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
External identifiers
- HGNC symbol
- NF1
- HGNC
- HGNC:7765
- UniProt
- P21359
Identifiers were checked against the public registry (HGNC, UniProt, MONDO via EBI OLS, NCBI GEO) and are listed only when certain.
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| NF1 | associated with | Mesenchymal-like state | high | VC0059 supports |
Appears in research topics
- Mesenchymal-like (MES-like) glioblastoma cell state (Cell states)
Appears in library items (1)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0059 An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. — Neftel C et al., Cell, 2019
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.