H3 K27M mutation
Also known as: H3K27M · H3-K27M
Histone H3 K27M mutation that defines H3K27M gliomas (diffuse midline glioma). Single-cell studies describe developmental and OPC-like programs in these tumors and map their cell states and spatial organisation across age and location. VC0064 VC0065
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| H3 K27M mutation | associated with | Oligodendrocyte-progenitor-like state | high | VC0064 supports OPC-like programs in H3K27M gliomas; the library notes these may not be equivalent to GBM OPC-like states. |
| H3 K27M mutation | associated with | Diffuse midline glioma, H3 K27-altered | high | VC0064 supports VC0065 supports |
Appears in research topics
Appears in library items (2)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0065 The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. — Liu I et al., Nature genetics, 2022
- VC0064 Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. — Filbin MG et al., Science (New York, N.Y.), 2018
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.