状态转变

细胞如何在状态间转换——治疗、微环境与时间作用下的可塑性。

关联证据

• VC0097 Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors. — Jungwirth G et al., NPJ precision oncology, 2026
• VC0134 TumorTwin: a Python framework for patient-specific digital twins in oncology — Kapteyn et al., BMC Med Inform Decis Mak, 2026
• VC0089 A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma. — Sussman JH et al., Cell reports. Medicine, 2026
• VC0132 Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations — Suter et al., Nature Communications, 2026
• VC0095 BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma. — Vadla R et al., Neuro-oncology, 2025
• VC0129 · 预印本 DELPHAI, AI Agent for Predicting Drug Response and Resistance — Peng et al., preprint, 2025
• VC0073 Multiscale mathematical model-informed reinforcement learning optimizes combination treatment scheduling in glioblastoma evolution. — Liu Z, Zhang J, Hong L, Nie Q, Sun X., Science advances, 2025
• VC0048 Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines. — Ahlmann-Eltze C, Huber W, Anders S., Nature methods, 2025
• VC0066 Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. — Hara T et al., Cancer cell, 2025
• VC0093 · 预印本 Spatial epigenomic niches underlie glioblastoma cell state plasticity — Kint S et al., bioRxiv, 2025
• VC0070 In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma. — Liu SJ et al., Genome biology, 2024
• VC0069 A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets. — Wang L, Jung J, Babikir H, Shamardani K, Jain S, Feng X, Gupta N, Rosi S, Chang S, Raleigh D, Solomon D, Phillips JJ, Diaz AA., Nature cancer, 2022
• VC0059 An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. — Neftel C et al., Cell, 2019