Tahoe-100M: Mapping drug-induced molecular phenotypes at single-cell resolution.
Zhang J et al. · Cell · 2026-09-01
Tahoe-100M正式发表于Cell 2026。
标签：药物反应
共 7 条，按时间倒序。
PerturbLDM: conditional latent diffusion for modelling single-cell perturbation responses
Yu et al. · bioRxiv · 2026-08-12
PerturbLDM：在Tahoe-100M上预训练的条件潜扩散模型，生成药物/剂量/细胞系扰动的单细胞响应。
Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors.
Jungwirth G et al. · NPJ precision oncology · 2026-06-16
自动化个体化GBM类器官药筛平台。
Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations
Suter et al. · Nature Communications · 2026-01-07
scFOCAL/ISOSCELES：把GBM细胞状态接到L1000药签，预测状态敏感度并验证OLIG2抑制剂+Depatux-M。
DELPHAI, AI Agent for Predicting Drug Response and Resistance
Peng et al. · preprint · 2025-09-17
DELPHAI：GBM类器官+TMZ的单细胞扰动预测与LLM机制解读；最优传输+PCA优于基线。
Tahoe-100M : A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling
Zhang J et al. · bioRxiv · 2025-02-24
Tahoe-100M：1亿细胞、1100药物×50肿瘤细胞系。
Predicting cellular responses to complex perturbations in high-throughput screens.
Lotfollahi M et al. · Molecular systems biology · 2023-05-08
CPA：组合扰动自编码器，预测药物/剂量/组合反应。