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Tag: Perturb-seq

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preprint✓ VerifiedVC0139

Engineered regulatory states resolve context-dependent genetics in macular degeneration

Metzner E, Guruvayurappan K, Southard KM, Ardy RC, Dey KK, Norman TM. · bioRxiv · 2026-10-12

Norman/Dey labs (MSKCC): CRISPRa Multiome Perturb-seq of 119 TFs + dual-guide Perturb-seq of 1,225 TF pairs in RPE-1; chromatin priming predicts emergent states; Mosaic (Transformer) predicts TF-pair interaction residuals (r=0.484) and nominated a validated triple-TF combination.

preprint✓ VerifiedVC0046

Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping

Swinderman JT et al. · bioRxiv · 2026-02-05

Probe-based scalable single-cell profiling for virtual-cell perturbation mapping.

dataset✓ VerifiedVC0045

X-Atlas/Orion: Genome-wide Perturb-seq Datasets via a Scalable Fix-Cryopreserve Platform for Training Dose-Dependent Biological Foundation Models

Huang AC et al. · bioRxiv · 2025-06-16

X-Atlas/Orion: genome-wide Perturb-seq datasets (Xaira).

paperBrain tumor✓ VerifiedVC0070

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.

Liu SJ et al. · Genome biology · 2024-10-07

In vivo Perturb-seq of GBM and microenvironment dissects drivers and radiotherapy responses.

dataset✓ VerifiedVC0040

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.

Replogle JM et al. · Cell · 2022-06-09

Genome-scale Perturb-seq (Replogle et al.): K562/RPE1 benchmark data.