{"id":"olig2","type":"gene","name_en":"OLIG2 (oligodendrocyte transcription factor 2)","name_zh":"OLIG2（少突胶质细胞转录因子 2）","aliases":["OLIG2"],"description":{"en":"scFOCAL linked GBM cell states to drug signatures and identified a combination of an OLIG2 inhibitor with Depatux-M as state-specific sensitivity.","zh":"scFOCAL 将 GBM 细胞状态与药物特征谱关联，并识别出 OLIG2 抑制剂联合 Depatux-M 的状态特异敏感性组合。"},"externalIds":{"hgnc_symbol":"OLIG2","hgnc_id":"HGNC:9398","uniprot":"Q13516"},"graphNames":[],"mentions":{"items":["VC0132"],"topics":["cell-state-npc-opc-like"]},"evidenceRefs":["VC0132"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/olig2/","page_url_zh":"https://gliostate.com/zh/entities/olig2/","api_url":"https://gliostate.com/api/entities/olig2.json","external_links":[{"scheme":"HGNC","id":"HGNC:9398","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9398"},{"scheme":"UniProt","id":"Q13516","url":"https://www.uniprot.org/uniprotkb/Q13516/entry"}],"source_file":"https://gliostate.com/data/entities/olig2.json","evidence_items":[{"id":"VC0132","title":"Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations","year":"2026","page_url":"https://gliostate.com/library/VC0132/","api_url":"https://gliostate.com/api/items/VC0132.json"}],"mentioned_in_items":[{"id":"VC0132","title":"Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations","year":"2026","page_url":"https://gliostate.com/library/VC0132/","api_url":"https://gliostate.com/api/items/VC0132.json"}],"mentioned_in_topics":[{"id":"cell-state-npc-opc-like","title_en":"Neural-progenitor-like (NPC-like) and OPC-like glioma cell states","title_zh":"神经前体样（NPC 样）与少突前体样（OPC 样）胶质瘤细胞状态","url":"https://gliostate.com/cell-states/neural-progenitor-like-opc-like/","api_url":"https://gliostate.com/api/topics/cell-state-npc-opc-like.json"}],"relations":[],"related_entities":[{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"scfocal","type":"model","name_en":"scFOCAL / ISOSCELES","name_zh":"scFOCAL / ISOSCELES","page_url":"https://gliostate.com/entities/scfocal/","page_url_zh":"https://gliostate.com/zh/entities/scfocal/","api_url":"https://gliostate.com/api/entities/scfocal.json","via":"co-mention"},{"id":"cdk4","type":"gene","name_en":"CDK4 (cyclin dependent kinase 4)","name_zh":"CDK4（细胞周期蛋白依赖性激酶 4）","page_url":"https://gliostate.com/entities/cdk4/","page_url_zh":"https://gliostate.com/zh/entities/cdk4/","api_url":"https://gliostate.com/api/entities/cdk4.json","via":"co-mention"},{"id":"diffuse-midline-glioma","type":"disease","name_en":"Diffuse midline glioma, H3 K27-altered (DMG)","name_zh":"弥漫性中线胶质瘤，H3 K27 改变型（DMG）","page_url":"https://gliostate.com/entities/diffuse-midline-glioma/","page_url_zh":"https://gliostate.com/zh/entities/diffuse-midline-glioma/","api_url":"https://gliostate.com/api/entities/diffuse-midline-glioma.json","via":"co-mention"},{"id":"foundation-model","type":"method","name_en":"Single-cell foundation model","name_zh":"单细胞基础模型","page_url":"https://gliostate.com/entities/foundation-model/","page_url_zh":"https://gliostate.com/zh/entities/foundation-model/","api_url":"https://gliostate.com/api/entities/foundation-model.json","via":"co-mention"},{"id":"glial-progenitor-like-state","type":"cell_state","name_en":"Glial-progenitor-like cells","name_zh":"胶质祖细胞样细胞","page_url":"https://gliostate.com/entities/glial-progenitor-like-state/","page_url_zh":"https://gliostate.com/zh/entities/glial-progenitor-like-state/","api_url":"https://gliostate.com/api/entities/glial-progenitor-like-state.json","via":"co-mention"},{"id":"h3k27m","type":"gene","name_en":"H3 K27M mutation","name_zh":"H3 K27M 突变","page_url":"https://gliostate.com/entities/h3k27m/","page_url_zh":"https://gliostate.com/zh/entities/h3k27m/","api_url":"https://gliostate.com/api/entities/h3k27m.json","via":"co-mention"},{"id":"idh-mutant-glioma","type":"disease","name_en":"IDH-mutant glioma","name_zh":"IDH 突变型胶质瘤","page_url":"https://gliostate.com/entities/idh-mutant-glioma/","page_url_zh":"https://gliostate.com/zh/entities/idh-mutant-glioma/","api_url":"https://gliostate.com/api/entities/idh-mutant-glioma.json","via":"co-mention"}]}