{"id":"mes-like-state","type":"cell_state","name_en":"Mesenchymal-like (MES-like) state","name_zh":"间充质样（MES 样）状态","aliases":["MES-like","mesenchymal-like","MES"],"description":{"en":"One of four recurrent malignant cell states of glioblastoma described by Neftel et al. (2019), alongside NPC-like, OPC-like and AC-like. Studies in the library link transitions toward MES-like or mesenchymal programs to cancer–immune cell interactions, BRD2 and recurrence after therapy.","zh":"Neftel 等（2019）描述的胶质母细胞瘤四种反复出现的恶性细胞状态之一，另外三种为 NPC 样、OPC 样与 AC 样。文献库中的研究将向 MES 样/间充质程序的转变与癌细胞-免疫细胞相互作用、BRD2 及治疗后复发相关联。"},"externalIds":{},"graphNames":["MES-like state"],"mentions":{"items":["VC0059","VC0066"],"topics":["cell-state-mes-like","transition-therapy-induced-plasticity","validation-gbm-state-replication"]},"evidenceRefs":["VC0059","VC0066","VC0095","VC0069"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/mes-like-state/","page_url_zh":"https://gliostate.com/zh/entities/mes-like-state/","api_url":"https://gliostate.com/api/entities/mes-like-state.json","external_links":[],"source_file":"https://gliostate.com/data/entities/mes-like-state.json","evidence_items":[{"id":"VC0059","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","year":"2019","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"},{"id":"VC0066","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","year":"2025","page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0095","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","year":"2025","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"},{"id":"VC0069","title":"A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.","year":"2022","page_url":"https://gliostate.com/library/VC0069/","api_url":"https://gliostate.com/api/items/VC0069.json"}],"mentioned_in_items":[{"id":"VC0059","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","year":"2019","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"},{"id":"VC0066","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","year":"2025","page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"}],"mentioned_in_topics":[{"id":"cell-state-mes-like","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"id":"transition-therapy-induced-plasticity","title_en":"Therapy-induced plasticity in glioblastoma","title_zh":"胶质母细胞瘤的治疗诱导可塑性","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"},{"id":"validation-gbm-state-replication","title_en":"Do Neftel-style GBM state calls replicate across platforms? A GlioState re-analysis (draft)","title_zh":"Neftel 式 GBM 状态判定能否跨平台复现？GlioState 再分析（初稿）","url":"https://gliostate.com/validation/gbm-state-call-replication/","api_url":"https://gliostate.com/api/topics/validation-gbm-state-replication.json"}],"relations":[{"subject":"nf1","subject_name_en":"NF1 (neurofibromin 1)","subject_name_zh":"NF1（神经纤维瘤蛋白 1）","predicate":"associated_with","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"high","evidence":[{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":null,"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}]},{"subject":"brd2","subject_name_en":"BRD2 (bromodomain containing 2)","subject_name_zh":"BRD2（含溴结构域蛋白 2）","predicate":"promotes","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"high","evidence":[{"id":"VC0095","role":"supports","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"note":{"en":"Evidence is from patient-derived xenograft and cell models: PTEN loss recruited BRD2 to MES gene promoters and bromodomain ablation reversed the MES transition.","zh":"证据来自患者来源异种移植与细胞模型：PTEN 缺失使 BRD2 被招募至 MES 基因启动子，溴结构域敲除逆转 MES 转变。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]},{"subject":"ap-1","subject_name_en":"AP-1 transcription factor complex","subject_name_zh":"AP-1 转录因子复合物","predicate":"promotes","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"medium","evidence":[{"id":"VC0069","role":"supports","title":"A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.","page_url":"https://gliostate.com/library/VC0069/","api_url":"https://gliostate.com/api/items/VC0069.json"}],"note":{"en":"Reported as mediating the mesenchymal shift in recurrent tumors; this is an observation at recurrence and does not show whether therapy induces or selects the state.","zh":"报告其介导复发肿瘤的间充质转变；这是复发时的观察，不能区分治疗是诱导还是筛选了该状态。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]},{"subject":"neftel-meta-modules","subject_name_en":"Neftel meta-modules","subject_name_zh":"Neftel 元模块","predicate":"marks","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"medium","evidence":[{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":{"en":"Signature-score calls from the Neftel meta-modules are not ground truth; the signatures used in GlioState’s re-analysis were an unverified third-party transcription.","zh":"由 Neftel 元模块得到的特征得分判定并非真值；GlioState 再分析所用特征为未经核验的第三方转录。"},"sources":[{"kind":"topic","id":"validation-gbm-state-replication","url":"https://gliostate.com/validation/gbm-state-call-replication/","api_url":"https://gliostate.com/api/topics/validation-gbm-state-replication.json"}]},{"subject":"pten","subject_name_en":"PTEN (phosphatase and tensin homolog)","subject_name_zh":"PTEN（磷酸酶与张力蛋白同源物）","predicate":"suppresses","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0095","role":"supports","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"note":{"en":"Inferred from loss-of-function wording only (“PTEN loss recruited BRD2 to MES gene promoters”); the library text does not state that intact PTEN suppresses the MES-like state. Needs review.","zh":"仅由功能缺失的表述推断（“PTEN 缺失使 BRD2 被招募至 MES 基因启动子”）；文献库文本并未说明完整的 PTEN 抑制 MES 样状态。需复核。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}]},{"subject":"nf-kb","subject_name_en":"NF-κB signalling","subject_name_zh":"NF-κB 信号通路","predicate":"associated_with","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0095","role":"supports","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"note":{"en":"Taken from the topic summary (“BRD2/NF-κB signalling”); the specific NF-κB statement was not independently re-checked against the paper. Needs review.","zh":"取自专题摘要（“BRD2/NF-κB 信号”）；NF-κB 的具体表述未对照论文独立复核。需复核。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}]},{"subject":"hypoxia","subject_name_en":"Hypoxia","subject_name_zh":"缺氧","predicate":"associated_with","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0061","role":"supports","title":"Integrative spatial analysis reveals a multi-layered organization of glioblastoma.","page_url":"https://gliostate.com/library/VC0061/","api_url":"https://gliostate.com/api/items/VC0061.json"},{"id":"VC0094","role":"supports","title":"Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.","page_url":"https://gliostate.com/library/VC0094/","api_url":"https://gliostate.com/api/items/VC0094.json"}],"note":{"en":"The library text says cell-state layers appear driven by hypoxia; it does not tie hypoxia to MES-like specifically. Needs review.","zh":"文献库文本称细胞状态分层似受缺氧驱动，并未将缺氧特异地与 MES 样状态绑定。需复核。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}]},{"subject":"radiotherapy","subject_name_en":"Radiotherapy","subject_name_zh":"放射治疗","predicate":"associated_with","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0069","role":"supports","title":"A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.","page_url":"https://gliostate.com/library/VC0069/","api_url":"https://gliostate.com/api/items/VC0069.json"}],"note":{"en":"Recurrent GBM shows a mesenchymal shift after therapy, but whether therapy induces or selects MES-like cells is unresolved.","zh":"复发 GBM 在治疗后出现间充质转变，但治疗是诱导还是筛选 MES 样细胞尚未解决。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]},{"subject":"npc-like-state","subject_name_en":"Neural-progenitor-like (NPC-like) state","subject_name_zh":"神经祖细胞样（NPC 样）状态","predicate":"transitions_to","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0066","role":"supports","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":{"en":"The library states that cancer–immune interactions drive transitions toward MES-like states and that cells can move between Neftel states, but does not name the source state; applied to all three non-MES states for review.","zh":"文献库称癌-免疫相互作用驱动向 MES 样状态的转变且细胞可在 Neftel 状态间移动，但未指明起始状态；此处对三种非 MES 状态均作标注，待复核。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]},{"subject":"opc-like-state","subject_name_en":"Oligodendrocyte-progenitor-like (OPC-like) state","subject_name_zh":"少突胶质前体细胞样（OPC 样）状态","predicate":"transitions_to","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0066","role":"supports","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":{"en":"The library states that cancer–immune interactions drive transitions toward MES-like states and that cells can move between Neftel states, but does not name the source state; applied to all three non-MES states for review.","zh":"文献库称癌-免疫相互作用驱动向 MES 样状态的转变且细胞可在 Neftel 状态间移动，但未指明起始状态；此处对三种非 MES 状态均作标注，待复核。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]},{"subject":"ac-like-state","subject_name_en":"Astrocyte-like (AC-like) state","subject_name_zh":"星形胶质细胞样（AC 样）状态","predicate":"transitions_to","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0066","role":"supports","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":{"en":"The library states that cancer–immune interactions drive transitions toward MES-like states and that cells can move between Neftel states, but does not name the source state; applied to all three non-MES states for review.","zh":"文献库称癌-免疫相互作用驱动向 MES 样状态的转变且细胞可在 Neftel 状态间移动，但未指明起始状态；此处对三种非 MES 状态均作标注，待复核。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]}],"related_entities":[{"id":"nf1","type":"gene","name_en":"NF1 (neurofibromin 1)","name_zh":"NF1（神经纤维瘤蛋白 1）","page_url":"https://gliostate.com/entities/nf1/","page_url_zh":"https://gliostate.com/zh/entities/nf1/","api_url":"https://gliostate.com/api/entities/nf1.json","via":"relation"},{"id":"brd2","type":"gene","name_en":"BRD2 (bromodomain containing 2)","name_zh":"BRD2（含溴结构域蛋白 2）","page_url":"https://gliostate.com/entities/brd2/","page_url_zh":"https://gliostate.com/zh/entities/brd2/","api_url":"https://gliostate.com/api/entities/brd2.json","via":"relation"},{"id":"ap-1","type":"pathway","name_en":"AP-1 transcription factor complex","name_zh":"AP-1 转录因子复合物","page_url":"https://gliostate.com/entities/ap-1/","page_url_zh":"https://gliostate.com/zh/entities/ap-1/","api_url":"https://gliostate.com/api/entities/ap-1.json","via":"relation"},{"id":"neftel-meta-modules","type":"method","name_en":"Neftel meta-modules","name_zh":"Neftel 元模块","page_url":"https://gliostate.com/entities/neftel-meta-modules/","page_url_zh":"https://gliostate.com/zh/entities/neftel-meta-modules/","api_url":"https://gliostate.com/api/entities/neftel-meta-modules.json","via":"relation"},{"id":"pten","type":"gene","name_en":"PTEN (phosphatase and tensin homolog)","name_zh":"PTEN（磷酸酶与张力蛋白同源物）","page_url":"https://gliostate.com/entities/pten/","page_url_zh":"https://gliostate.com/zh/entities/pten/","api_url":"https://gliostate.com/api/entities/pten.json","via":"relation"},{"id":"nf-kb","type":"pathway","name_en":"NF-κB signalling","name_zh":"NF-κB 信号通路","page_url":"https://gliostate.com/entities/nf-kb/","page_url_zh":"https://gliostate.com/zh/entities/nf-kb/","api_url":"https://gliostate.com/api/entities/nf-kb.json","via":"relation"},{"id":"hypoxia","type":"pathway","name_en":"Hypoxia","name_zh":"缺氧","page_url":"https://gliostate.com/entities/hypoxia/","page_url_zh":"https://gliostate.com/zh/entities/hypoxia/","api_url":"https://gliostate.com/api/entities/hypoxia.json","via":"relation"},{"id":"radiotherapy","type":"method","name_en":"Radiotherapy","name_zh":"放射治疗","page_url":"https://gliostate.com/entities/radiotherapy/","page_url_zh":"https://gliostate.com/zh/entities/radiotherapy/","api_url":"https://gliostate.com/api/entities/radiotherapy.json","via":"relation"},{"id":"npc-like-state","type":"cell_state","name_en":"Neural-progenitor-like (NPC-like) state","name_zh":"神经祖细胞样（NPC 样）状态","page_url":"https://gliostate.com/entities/npc-like-state/","page_url_zh":"https://gliostate.com/zh/entities/npc-like-state/","api_url":"https://gliostate.com/api/entities/npc-like-state.json","via":"relation"},{"id":"opc-like-state","type":"cell_state","name_en":"Oligodendrocyte-progenitor-like (OPC-like) state","name_zh":"少突胶质前体细胞样（OPC 样）状态","page_url":"https://gliostate.com/entities/opc-like-state/","page_url_zh":"https://gliostate.com/zh/entities/opc-like-state/","api_url":"https://gliostate.com/api/entities/opc-like-state.json","via":"relation"},{"id":"ac-like-state","type":"cell_state","name_en":"Astrocyte-like (AC-like) state","name_zh":"星形胶质细胞样（AC 样）状态","page_url":"https://gliostate.com/entities/ac-like-state/","page_url_zh":"https://gliostate.com/zh/entities/ac-like-state/","api_url":"https://gliostate.com/api/entities/ac-like-state.json","via":"relation"}]}